Lucy Carter, a widow with two teen children, takes a job as a secretary for her stuffy brother-in-law.
When Luke Calhoun loses all his money in a stock scheme, he and his daughter Meena stay at the Ponderosa with disruptive consequences. Luke turns the ranch into a casino and Meena continues her frantic search for a husband, where she left off in season eleven's "Meena".
Syndicate members Trask and Mason control the Syndicate's illegal racing operations, while Trask ruthlessly dispatches the competition - the IMF must take them out. Trask is jealous of thoroughbred owner Mason so Jim offers him a mysterious but promising racehorse - Trask finds out the horse is a kidnapped fast-racer. The IMF arrange for him to get the horse and then place a number of bets on the horse in Trask's name. After keeping Mason from having the horse killed, Trask's horse wins and the IMF get the $4 million from the Syndicate funds, leaving Trask to hold the bag.
When Edie is out of town, Lou hires Rhoda to redecorate his living room. However, Rhoda's tastes are too modern.
Everyone in the family is sick, so Edith calls Cousin Maude to help out.
Marcia makes a promise that she will get Davy Jones to perform at the prom. A promise she quickly learns is going to be very difficult to keep, since trying to get a hold of him is almost impossible.
When Danny and Brett find the decade-old dead body of a scientist in a crashed plane in the Scottish Highlands, several women claiming to be his daughter offer them various inducements to part with the formula they found.
Disgusted at the awful cuisine served up at Ye Olde Shepherds Restaurant, the Goodies head to the farm of Tim's uncle for some fresh country food, only to be further disappointed upon arrival.
Oscar is happy that his ex-wife is remarrying, and there would be no more alimony. But Felix wants to stop the marriage.
Hannibal Heyes and Kid Curry, two of the most wanted outlaws in the history of the West, are popular "with everyone except the railroads and the banks".
A haunting love story of a young woman and her late father's colleague, a man clinging desperately to life in a refrigerated apartment. A heartless moneylender gets his just desserts with the help of a client's unusual telescopic device. Edgar Allan Poe receives some unwanted coaching during a bout with writer's block.
Endora tries to make Samantha jealous again by recruiting a beautiful, sexy witch named Ophelia on Darrin. Ophelia tries anything to get Darrin to come to a sales convention, even fake stage fright. Darrin intentions are to spend time with Samantha, but Larry Tate intervenes. Darrin goes but decides to take a late plane back, but the unrelenting Ophelia disguises herself as an airport manager, informing Darrin the airport is closed due to fog. Endora suggests to Samantha that fog is not the reason Darrin is not coming home. Sam realizes that there is something fishy going on pops in to see what is up. With a little magic, Darrin realizes that Sam is his real love and Endora's in the hot seat.
The trio investigates after an innocent bystander is killed by a speeding car after it narrowly misses Pete.
As the train moves along to Denver we meet several passengers. One is a Pinkerton man handcuffed to Beth Tilton, a woman who doesn't want to go back to Colorado to her husband. The other, Allie Dawson, is a young girl that Newly befriends who does not believe in violence. The train is taken over by Jack Sinclair, an old enemy of Matt's. Matt had shot his hand off before sending him to prison. Making it look like Matt is a dead body in the baggage car, he is safe for now with Doc standing guard, but it can't last long. Kitty senses trouble when Beth starts cozying up to Jack Sinclair and worries she'll tell him what she knows. Warning her that she'll do anything for her man, Kitty watches Beth like a hawk. Festus and Newly are forced to help load the gold shipment on the wagon and when they get it loaded they end up driving off with it luring the gang out on foot to chase them. Beth tells one of the guards about Dillon in the back, and he goes to kill him.
Lucy Carter, a widow with two teen children, takes a job as a secretary for her stuffy brother-in-law.
Jamie and three teen-agers - a girl and two boys - are kidnapped by Doyle, a hardened criminal with nothing to lose, and his gang of outlaws. The desperate outlaws use the youths as bargaining tools to make their escape from a trip to prison.
Wendell Hayes, the brother of an imprisoned Syndicate enforcer, has stolen a canister of nerve gas and threatens to use it if his brother Cayman isn't freed - the IMF must stop him and recover the gas. Worse, the canister has a defective casing that Wendell is unaware of, and will release the gas in 43 hours anyway. And...Cayman dies of a heart attack in jail, forcing the IMF to have guest-agent Bill Williams take his place. The IMF has Hayes' imprisoned girlfriend Saretta ""escape"" with prisoner-Casey handcuffed to her. Saretta takes Casey to a winery in a IMF car with a bug on it that Barney traces. Jim delivers ""Cayman"" but Hayes doesn't turn over the gas. They track Hayes to an observatory but he gets word via his partner Tully that his brother tied and he unmasks Williams-as-Cayman. Hayes and Tully shoot it out over an argument and with his dying breath Hayes tries to shoot open the canister...hid in the observatory roof, revealing its location to the IMF.
Rhoda loses her job as a window-dresser and isn't in a hurry to find something new. When there is a job opening at WJM-TV, Mary lies to Rhoda and tells her the job has been filled, to Lou's surprise.