With the assistance of Peyton and Brooke, Lucas throws Nathan and Haley a wedding reception. Although Haley's parents support the marriage, Deb has a difficult time accepting it. Meanwhile, Dan's recent heart attack causes him to try and mend his relationships with Deb and Lucas.
With Carmen still gone, George goes on a hunt for her and eventually finds her in San Francisco with rapper Chingy. He finally gets her to return home, but the problems aren't over yet...
Richie is on the S.S. Anne when a school of wild Gyarados block the waters ahead. The crew is about to take the long way around, but a grizzled Trainer named Silver orders his Salamence to send the Gyarados packing so the trip can continue. Silver also has a Chikorita, and a lifelong mission: to battle the Legendary Moltres! But Richie thinks there's something suspicious about the two researchers with Silver, especially when the ship docks at an evacuated volcanic island and Richie sees the three of them sneaking onto the shore. Richie jumps ship and follows them, convinced something is up. When he catches them headed for the top of the volcano, they tell him Moltres should appear at this volcano tomorrow. The researchers want to sample Moltres's fire for scientific reasons, so they enlisted Silver's help—and they don't want Richie tagging along. However, Richie later overhears the researchers talking, and they're really Butch and Cassidy!
Ellie and Sean are getting closer than ever, so close that he wants her to move in but she denies him but it might not be such a bad idea when her house catches on fire. Meanwhile at the spirit squad car wash, Paige is sick and Spinner has his eye on....Manny?
After being fired from the DOT it seems she'll never be able to pay Spin back for what she did to his car, but that's not all she may have to worry about as Hazel shows her some convincing photos of foul play. Meanwhile in Mr.Simpsons MI class Toby and Rick partner up but they start to compete for who can get more kisses.
Cheryl surprises Jim with a romantic evening, but it cuts into his planned TV boxing match.
Eric Camden, a minister, and his wife Annie deal with the drama of having seven children, ranging from toddlers to adults with families of their own.
A woman is killed during a posh party at an exclusive waterfront estate when a man opens fire on the proceedings from a cigarette boat. When a former con is arrested, he acts as his own lawyer and proves to be smarter than he appears. Complicating matters is the fact that the leading witness in the case is the dead woman's 10-year-old son, whom Horatio wants to protect, refusing to let him testify.
Mona and Dee Dee agree to get each other dates as a birthday present. Dee Dee does some thorough research and finds Mona a seemingly perfect guy, James, and the two get along well enough to set up a second date. Mona waits until the last minute to begin her search and is forced to turn to a less-than-helpful Spencer and Adam as she tries desperately to track down someone for her sister. Meanwhile, Dee Dee convinces a reluctant Big Dee Dee to let Mona and Phyllis join them for a mother/daughter portrait sitting. Big Dee Dee and Phyllis see the photograph as another opportunity to outdo each other and go all out to find the flashiest outfits possible.
When an accident to Flex's co-host puts his syndication deal in jeopardy, Flex comes up with a great idea to have a sports show with his buddies, but before he has a chance to pitch the concept, he finds himself forced to take on his boss' new Croatian girlfriend as his new sidekick.
Toni's friends refuse to believe that she is pregnant, as they are certain it is all part of a ploy to win back Todd. Even after Toni shows them an ultrasound and experiences morning sickness, they still believe that she is lying and insist on tagging along to her doctor's appointment. After her pregnancy is confirmed, an apologetic Todd comes home to help care for her, but remains unsure about their relationship. Meanwhile, William grows fed up with Maya's poor performance at the office and places her on probation after her antics with client Rev. Al Sharpton (including giving him a copy of her book) prompt Sharpton to give William a lecture.
Ephram regrets promising Nina that he would watch over Hannah at school, especially when her constant presence interferes with his time alone with Amy. Amy befriends Hannah out of a sense of charity, but soon finds Hannah so refreshing that a real friendship develops. Meanwhile, Andy tries to ignore the tension between Dr. Abbott and Edna, but his attitude forces Edna to quit and go to work for Dr. Hartman. Andy treats a 13-year-old patient (guest-star Carter Jenkins) whose mysterious injuries cause Andy to suspect the boy's mother (guest-star Elizabeth Mitchell) of abuse.
Judith is dating Jake's pediatrician, and Alan is upset until Charlie points out that if she remarries, his alimony payments will end.
The sun rises as moose graze in Kidney Pond in Maine, under the shadow of the 4,000 ft. peak of Katahdin Mountain
Leo, Harry and Nikki step up their efforts to discover the truth behind the train crash but there are still many unanswered questions.
When Ray and Debra visit Frank and Marie's condo in the retirement community, they learn that they are going to be kicked out due to a number of complains from the other residents.
Sportacus tries on a new pair of shoes, unaware that they are actually radio-controlled boots that Robbie will use to ruin Sportacus' athletic skills during Spectacular Sports Day.
Ed is framed for murder when enemies from his past resurface. Danny and Mike secretly intervene to investigate and take matters into their own hands. Meanwhile, Sam, Nessa, Mary and Delinda desperately attempt to find tenants for their new joint-purchased home, settling on what they think to be the perfect tenants, only to discover they've misjudged the situation.
Teachers: Ned clashes with Mr. Sweeney and realizes how to get an A, by doing the work! Moze has a new student teacher in math who she devises a plan with so the class with listen after it has gone crazy. Cookie is distracted by the beautiful Ms. Enstile and tries to control his affection toward her. Detentions: Ned, Cookie and Moze are sent to detention.