Dr. Cox starts drinking after his decisions result in the death of three of his patients. The staff tries to cover for him at the hospital, while everyone tries to convince him how inspiring he is for them. Turk starts his new rotation with orthopedic surgery, but isn't so fond of his attending doctor's touchy-feely methods. Thus, J.D. and the Janitor attempt to help Turk find ways to bond with his new supervisor.
Mammoth Mutt, Tail Terrier, and Paw Pooch compete for temporary leader when Brainy gets put to sleep by sleeping gas.
When a proud and happy Ryan announces that Dana is pregnant, Jim warns him of Dana's upcoming hormone swings, and ends up dreaming that he is pregnant.
Name partner Edwin Poole returns from a mental institution to Crane, Poole and Schmidt, ready to jump back in, but Shirley has reservations when he decides to sue a candy company. An A.D.A. with a grudge against Alan brings charges, accusing him of advising his client to flee when a guilty verdict was inevitable. Meanwhile, Brad and Denise decide where to take their relationship.
Stabler teams up with an new partner to investigate a sexual attack on Jessica DeLay, a sixteen-year-old girl who worked tobacco stings for the Department of Health and face an overweight young brother and sister who claim it was an act of vengeance for Jessica and her friend, Tommy Strahan, beating up their older brother Rudi for being fat. Stabler and Blaine arrest DeLay and Strahan, but when the two are released due to lack of admissable evidence, Rudi Bixton takes justice into his own hands.
Ephram discovers that Bright cheated on Hannah and confronts him about it. Irv takes Edna along on his book tour, where they meet his daughter Cassie. Reid is faced with expulsion from medical school for cheating on an exam. Harold confesses to Andy that he neglected to report Rose's cancer on the adoption application. Ephram tells Amy what happened with Bright, prompting her to confront him and force him to admit the truth to Hannah.
A cruise ship that is docked in Miami is the scene for a double murder. The team investigates the long list of potential suspects but soon find that the list is dramatically decreased when the CSI's find a large amount of money is missing from the victim's stateroom. Horatio and Marisol's relationship evolves.
Breanna's Uncle Kevin flies in from Baltimore to try selling his line of hair-care products to L.A. salons; Breanna refuses to let Arnaz bring any of his dates into the house.
Joan cuts loose two of the men she's dating when she develops feelings for an NBA player. A traumatic event lands Toni behind bars.
One night at the movie theatre, Doug and Carrie can't decide on which film they want to see. They run into Deacon and Kelly and it turns out Kelly wants to see what Doug wants to see and Deacon likes the movie that Carrie likes.
Isis steals a magical pipe that can control animals and uses it to rob stores in Metropolis. When Ace and Krypto end up under her spell, Jimmy the rat has to fight her off.
Trump's children, Ivanka and Donald Jr. fill in for Carolyn and George for this task, which requires the remaining candidates to promote one of New York City's biggest tourist attractions.
After stowing away aboard the flight containing Henderson's contact and the incriminating recording, Jack finds himself having to deal with a pilot who refuses to cooperate. Martha begins to break down, and Mike becomes suspicious of what she is hiding from him, while Logan tries to calm his financial backers.
Lily, Barney and Robin attend a high school prom to scout out a potential band for Lily and Marshall's wedding reception. In order to get in Lily and Robin pretend to be the dates of two kids who were going alone. Ted and Marshall are back at the apartment where they are preparing the invitations to be sent out.
Allison repeatedly dreams about a woman who is being watched by a stranger in her bedroom.
Westmoreland wants Michael to speed up the planned escape, and gets Bellick one step closer to unraveling it. Michael has to decide whether to involve Sara in the breakout plan. Tweener's devotion is put to a test. Veronica finds out that her ally unexpectedly has a connection to an inmate serving time at Fox River.
Jake’s teacher has a meeting with Alan and Judith to discuss the lack of interest Jake has at school. Alan starts to fall for Francine, in a platonic way, because he is tired of the lack of intelligent communication he has with Kandi. Charlie helps Jake audition for his school musical.
Christine tries not to have a meltdown when her ex-husband, Richard, brings his "new" Christine with him to pick up Ritchie and take him to breakfast so that they can get to know one another. By day's end, Christine tries to pull herself together to make a good impression at parents' night at Ritchie's school, but is caught off guard when "new" Christine shows up as well.
As Rose gets ready to make a huge announcement, Simon breaks down as he realizes that he may have trapped himself in a marriage that he does not want. Meanwhile, Eric and Annie reminisce about their children and their younger days as they prepare for the rehearsal dinner and meet Rose's unconventional parents.
Mona is taking her break-up with Chase out on everyone, only to realize that she's also putting her professional career in jeopardy. Dee Dee's newly signed client is married but when she suspects he's having an affair she is faced with a moral dilemma. Meanwhile, Phyllis and Big Dee Dee assume the girls are planning a big Mother's Day celebration, since neither has suggested plans to celebrate.