Dean is furious after Sam disappears to follow a lead on a case with clues that are identical to a case Sam solved as a kid. The demon turns out to be Amy, who has been killing low-life thugs and taking their brains for dinner - the same demon Sam found as a kid.
While interviewing doctors to run the clinic, Michael helps a man who passed out, but refuses care due to lack of insurance. Meanwhile, as Michael evaluates a woman, he notices lesions on her brain that require immediate surgery, even as he doesn't know the exact diagnosis.
Birkoff tells Nikita and Michael that a black box file reveals that an international terrorist named Ramon, who has been taking credit for some serious political assassinations, now works for Division. This news upsets Nikita since she was the agent that captured Ramon years ago and turned him over to Percy. Amanda convinces Alex to kill Anton Kochenko, a man who used to work for Alex's father, and plans to let Ramon take the credit for the murder. However, when Nikita disrupts Amanda's plan, Amanda fights back by taking what Nikita loves most.
Two young bullies are found dead and in just a few hours they rot to an advanced state of decomposition. The Fringe team investigates and uncovers an amorphous figure claiming more victims. Walter becomes increasingly distracted with his mental state.
Three men attempt to rob a bank and Danny discovers that one of the robbers is a former cop. Jamie starts working with Luisa Sosa, his new partner.
Cassie looks up an old friend of her mother's named Heather Barnes and discovers she has been in a catatonic state since the night of the fire 16 years ago. Feeling guilty that her mother and her Circle may have had something to do with Heather's current state, Cassie tells Diana that she wants to use magic to help Heather. Diana refuses to help, but Faye is more than happy to conjure up a spell - for a price.
Leslie's book about Pawnee comes out just in time for her campaign. Ann tries to bond with Ron and April.
A stampede at a comic book convention leads to an influx of colorful characters in the ER; Mark continues to make life difficult for Jackson; Ben returns and realizes Bailey has moved on.
Reese goes undercover to find the threat surrounding the next person on Finch's list: a young army veteran named Joey Durban.
The study group struggles to incorporate a fellow classmate while working on a project for Professor Kane's class.
Penny plays Matchmaker for Raj, which results in him finding a girl he is comfortable talking to.
When the son of a former client from Jane's days as a psychic is kidnapped, Jane and the CBI team are asked to help find him. Meanwhile, Jane butts heads with his former client's new "spiritual advisor."
Still in Chicago, Klaus uses Gloria, a witch he knew long ago, to help him track down missing information that will explain why his plan isn’t working. Gloria’s spells reveal intriguing glimpses of the truth, but she soon realizes she needs Stefan’s knowledge to complete the puzzle. When Stefan suddenly finds himself in danger, help comes from a surprising ally. Back in Mystic Falls, a frustrating new enemy pushes Damon over the brink and he lashes out in a way that will have lasting consequences. Caroline struggles with her own emotional issues, even as she tries to help Elena face her feelings. Jeremy makes a brief but disturbing breakthrough with one of his ghostly visitors, leaving him more confused than ever. Finally, Bonnie has a strange encounter that will affect everyone.
The entire warehouse staff quits after winning the lotto, leaving Andy and Darryl to scramble for replacements while several of the office workers get a taste of the warehouse life.
Dee faces an IRS audit over her claim that the baby she carried as a surrogate is her dependent, while the guys decide to run the bar in an unemotional, democratic manner rather than their typical method of shouting and personal attacks.
In the wilds of Africa, sometimes sheer numbers can decide who lives and dies. One African river is set to boiling with scales as crocodiles join forces to tear apart their prey.
A global cataclysm, caused by a fatal accident in Geneva (Switzerland) during the implementation of the particle accelerator will lead to the crew and students of the school-ship Polar Star to live the greatest adventure of their lives. Isolated and aware that we only have each other, the ship will become their only home.
It's Hector's 40th birthday and friends and family gather at his house for a BBQ. But in amongst the celebrations one of the guests slaps a child that is not his own. No-one can see it at the time but this single act begins to unravel the social fabric which once linked them all together.