Adrian hosts a baby shower. Lauren, Madison, Amy, and Grace all attend. Ricky finds out that Leo is having problems with stress.
When a destructive wildfire suddenly rips through the hills of Malibu, arson is immediately suspected. Once the blaze is contained, the detectives soon realize that a second fire was intended to cover up a gruesome crime. Meanwhile, DDA’s Dekker and Rubirosa stumble upon some information crucial to the case.
When Mo's keys fall into the pond, Poppy takes them on a submarine voyage to look for them.
Lorenzo's uncle,the duke,sets a competition to find Florence's finest painter and cocky Michelangelo taunts Leonardo that he cannot beat him so Machiavelli enlists Lorenzo's help in tricking Michelangelo into painting the duke's least preferred topic,angels and cherubs. Leonardo,however,is annoyed that he is expected to collude in cheating and deliberately erases the smile from the teen-aged version of La Gioconda which he painted using Lisa as his model,thus allowing her, as 'Tomaszo' to win.
Teresa receives two major blows: Teo's betrayal ends to a new love without her knowing it, and the past lies of the man who she believed to be her godfather are revealed.
When Chris and Martin meet up with a mob of Red kangaroos, they get their car keys stolen by a joey and have to figure out how to get them back from the tricky little guy.
XIII and Jones infiltrate a bunker to reach Max Serle, with Irina and her team in hot pursuit.
The team treats a performance artist (Shohreh Aghdashloo) who deliberately made herself ill with the aim of turning the diagnostics department into her new masterpiece, as House must decide which of her symptoms are real, and which are self-inflicted. As the case progresses, House vows to make changes in his life, but remains rooted in old habits. After the case is over, House finally deals with his anger over the breakup and lashes out by driving through Cuddy's dining room and escaping to a beach.
XIII and Dillon work frantically to break the password from an encrypted file.
Gerhardt has stolen the information weapon and is bent on using it to undermine world powers to his benefit.
Guy Fieri visits a fusion eatery in San Francisco that serves Korean spicy-pork burritos with homemade kimchee. Other stops include a Mexican joint in Indianapolis; and a Belizean restaurant in Chicago.
Billie and Mick continue to experience fertility problems and in desperation Billie asks Nina to consider being a surrogate for the couple without telling Mick of her plan. Darcy has another health scare while practicing for the honeymoon and Chris arrives back in time to see Nina kissing Fraser in the emergency department.
Gordon is in Malaysia where he quickly learns it’s the women and not the chefs that rule the kitchens. Gordon’s week is spent under the wing of some of the country’s best female cooks. He’s invited to cook his first Malaysian curry for the Prime Minister, scales great heights to find the key ingredient to bird’s nest soup before he’s entered into a cooking competition against some of the country’s hottest female cooks.
It's Halloween, and the aftermath of a christening gone awry leads to dramatic tricks and nary a treat. Meanwhile, the Brownstone hosts a fashion show. The catwalk sets the stage for catcalls and catfights, particularly when Kathy voices off and Caroline stands her ground.
The worldwide adventure continues when most teams struggle to find flights out of Indonesia. One team enquires about a bus off the island, while sparks fly when another couple can't agree on how to get to Vietnam.
Just when Jackie has run out of pills, she runs into a confrontation about the drugs from Oncology that disappeared. Coop tracks down an old girlfriend on Facebook when he decides to start his own family. Heart problems make Zoey revisit her relationship with Lenny.
Food is the ultimate aphrodisiac for a couple; a man becomes ill after the act of sex.
Ohana learns from Yuina that the Fukuya Inn is to be featured in a magazine, taking on a mystery guest. Meanwhile, the Kissuiso gets a sudden surge of customers with Nako and Tōru on their day off, but as Sui prepares to put in her share of the work, she suddenly starts feeling pain and is taken into hospital. After Ohana is told to return to work, she gets a call from Kō, who tries to tell her he is on his way to visit her, but she is unable to hear it. Arriving back, the staff, along with Takako, suspect that the inn may be hosting mystery guests from one of the magazines, suggesting that they prioritize their service over the other customers. However, after finding Sui's accounting book, Ohana stands up against her, saying that all customers need to be treated equal. Needing extra support to deal with the large number of customers, Ohana calls in Nako before going off to find Tōru, who is attending a wedding.